LONGEVITY CLUB: BERBERINE 500

Ingredients:

Berberine Hydrochloride:  500 mg per serving.

Recommended Use:

As a dietary supplement, adults take 1 (one) capsule, three times per day.

General Information and Actions:

Provides support for healthy glucose metabolism. Helps support healthy blood lipid levels. Helps support healthy cholesterol levels (serum triglyceride, total, and LDL).

Helps support cardiovascular health.

Cautions and Warnings:

If you have hypoglycemia, hypotension, a liver or kidney disorder, cardiovascular disease, diabetes, gall stones or a blood disorder, consult your health care professional before use.

Consult a health care practitioner prior to use if you are taking other medications or natural health products.

Contraindications:

Do not use if you are pregnant, breastfeeding, or if you have scleroderma.

Known adverse reactions:

Gastrointestinal discomfort (i.e., diarrhea, vomiting, nausea, abdominal pain, or constipation) has been known to occur; in which case, discontinue use and consult a health care practitioner.

References:

1.Yueshan Hu et al., Lipid-lowering effect of berberine in human subjects and rats, Phytomedicine 19 (2012) 861– 867

2.Hao Zang et al., Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression,  Metabolism Clinical and Experimental 59 (2010) 285–292

3.Zhao et al. , Efficacy and safety of berberine for dyslipidemia: study protocol for a randomized double-blind placebo-controlled trial, Trials, (2021) 22:85

4.Pérez-Rubio KG, González-Ortiz M, Martínez-Abundis E, Robles-Cervantes JA, Espinel-Bermúdez MC. Metab Syndr Relat Disord. 2013 Oct;11(5):366-9. doi: 10.1089/met.2012.0183. Epub 2013 Jun 28.

5.Jin Y, Khadka D, Cho WC. Pharmacological effects of berberine and its derivatives: a patent update. Expert Opin Ther Pat. 2016;26(2):229-243.